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Glaucine has also been demonstrated to be a dopamine receptor antagonist, favoring D1 and D1-like receptors. It is currently used as an antitussive agent sildenafil moa Iceland, as well as Romania, Bulgaria, Russia and other eastern European countries. These reports mirror those about the effects of clinical use, which state dissociative-type symptoms as well as lethargy, fatigue, hallucinations.

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Resource investigation and quality evaluation on wild Corydalis yanhusuo”. China journal of Chinese materia medica. Antifungal activity of the methanolic extract and alkaloids of Glaucium oxylobum”. Geographic distribution of three alkaloid chemotypes of Croton lechleri”. Bronchodilator and anti-inflammatory activities of glaucine: In vitro studies in human airway smooth muscle and polymorphonuclear leukocytes”. Objective evaluation of dextromethorphan and glaucine as antitussive agents”. A case of hallucinogen-like action of glaucine”. Acute glaucine syndrome in the physician’s practice: The clinical picture and potential danger”. Detection of the pharmaceutical agent glaucine as a recreational drug”.

Structure-affinity relationships of halogenated predicentrine and glaucine derivatives at D1 and D2 dopaminergic receptors: Halogenation and D1 receptor selectivity”. Neuroleptic-like, anticonvulsant and antinociceptive effects of aporphine alkaloids: Bulbocapnine, corytuberine, boldine and glaucine”. Archives Internationales de Pharmacodynamie et de Thérapie. In the case of anti-infective drug development, the information permits anticipation of problems relating to clinical safety. By knowing the interaction between a certain site of a drug and a receptor, other drugs can be formulated in a way that replicates this interaction, thus producing the same therapeutic effects. Indeed, this method is used to create new drugs. It can help identify which patients are most likely to respond to treatment. It can enable better dosing because the drug’s effects on the target pathway can be monitored in the patient. Statin dosage, for example, is usually determined by measuring the patient’s blood cholesterol levels. It allows drugs to be combined in such a way that the likelihood of drug resistance emerging is reduced.

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It may allow other indications for the drug to be identified. Bioactive compounds induce phenotypic changes in target cells, changes that are observable by microscopy, and which can give insight into the mechanism of action of the compound.

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